Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 1.473

Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

NameEntrezDescription
Fos 14281 FBJ osteosarcoma oncogene
Fosb 14282 FBJ osteosarcoma oncogene B
Fosl1 14283 fos-like antigen 1
Junb 16477 Jun-B oncogene
Jund 16478 Jun proto-oncogene related gene d

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Foschr12_+_868148220.791.2e-08Click!
Jundchr8_+_732236810.421.2e-02Click!
Junbchr8_-_875025920.163.4e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr2_+_156301543 23.052 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr3_+_55265811 13.232 Dclk1
doublecortin-like kinase 1
chr14_+_66587319 12.573 NM_013492
Clu
clusterin
chr10_+_128370814 11.192 NM_008398
Itga7
integrin alpha 7
chr2_-_17652669 10.446 NM_028757
Nebl
nebulette
chr14_+_35124004 10.332 Glud1
glutamate dehydrogenase 1
chr8_+_97508270 9.347 NM_018882
Gpr56
G protein-coupled receptor 56
chr8_+_56040445 9.342 Gpm6a
glycoprotein m6a
chr1_-_156731538 9.267 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr10_+_115580947 9.165 Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_+_136539202 8.939 Snap25
synaptosomal-associated protein 25
chr11_-_69479553 8.909 NM_009853
Cd68
CD68 antigen
chr10_-_80889856 8.793 NM_008688
NM_026756
Nfic

nuclear factor I/C

chr19_+_23215704 8.637 NM_010638
Klf9
Kruppel-like factor 9
chr1_-_33964439 8.105 NM_177235
Bend6
BEN domain containing 6
chr10_-_76188683 7.823 NM_009933
Col6a1
collagen, type VI, alpha 1
chr18_+_33098694 7.666 NM_009793
Camk4
calcium/calmodulin-dependent protein kinase IV
chr8_+_98226914 7.582 NM_001195006
NM_145602
Ndrg4

N-myc downstream regulated gene 4

chr18_+_77424573 7.446 NM_013666
NM_153124
St8sia5

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

chr10_+_60638341 7.429 Tbata
thymus, brain and testes associated
chr6_-_124719465 7.427 NM_013509
Eno2
enolase 2, gamma neuronal
chr2_-_73498303 7.377 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr1_+_109486582 7.360 NM_001159748
NM_011459
Serpinb8

serine (or cysteine) peptidase inhibitor, clade B, member 8

chr11_+_94797565 7.359 NM_007742
Col1a1
collagen, type I, alpha 1
chr7_-_116925058 7.266 NM_020610
Nrip3
nuclear receptor interacting protein 3
chr3_-_88307024 7.072 Lmna
lamin A
chr3_+_121426422 6.967 NM_010171
F3
coagulation factor III
chr7_-_31912022 6.791 Scn1b
sodium channel, voltage-gated, type I, beta
chr10_+_128346900 6.581 NM_007653
Cd63
CD63 antigen
chr13_-_8870975 6.546 NM_001039388
Wdr37
WD repeat domain 37
chr8_+_56040553 6.494 Gpm6a
glycoprotein m6a
chr2_+_131735663 6.445 NM_011170
Prnp
prion protein
chr17_-_90487479 6.426 Nrxn1
neurexin I
chr14_+_14117292 6.162 NM_028052
Synpr
synaptoporin
chr12_+_31950097 6.090 NM_008482
Lamb1
laminin B1
chr2_+_136539143 5.864 NM_011428
Snap25
synaptosomal-associated protein 25
chr13_-_56397521 5.732 Cxcl14
chemokine (C-X-C motif) ligand 14
chr7_-_90883999 5.413 NM_010551
Il16
interleukin 16
chr10_-_63552994 5.281 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_164268672 5.251 NM_011521
Sdc4
syndecan 4
chr14_+_14117313 5.167 Synpr
synaptoporin
chr5_-_149363989 5.036 Ubl3
ubiquitin-like 3
chr3_-_88307198 5.016 Lmna
lamin A
chr1_-_79436564 4.706 NM_009129
Scg2
secretogranin II
chr19_+_23215725 4.573 Klf9
Kruppel-like factor 9
chr19_+_26679649 4.527 NM_011416
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_+_4424140 4.511 NM_001161822
NM_019958
Rgs17

regulator of G-protein signaling 17

chr10_+_56097078 4.447 NM_010288
Gja1
gap junction protein, alpha 1
chr2_-_17652725 4.411 Nebl
nebulette
chr11_-_101032604 4.362 NM_146030
Plekhh3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr4_-_132768403 4.352 NM_008154
Gpr3
G-protein coupled receptor 3
chr2_+_25251393 4.284 NM_009849
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr14_-_14117143 4.218 NM_177813
Gm5087
predicted gene 5087
chr5_-_149363603 4.146 Ubl3
ubiquitin-like 3
chr11_+_59476181 4.038 Mprip
myosin phosphatase Rho interacting protein
chr17_+_45692647 4.014 NM_008690
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr17_-_27650285 3.906 Grm4
glutamate receptor, metabotropic 4
chr7_-_31911884 3.776 NM_011322
Scn1b
sodium channel, voltage-gated, type I, beta
chr2_+_25284190 3.687 NM_007379
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_+_42300005 3.628 Zyx
zyxin
chr1_+_6720153 3.583 St18
suppression of tumorigenicity 18
chr5_-_8367951 3.565 NM_001007220
NM_001007221
NM_001098225
Adam22


a disintegrin and metallopeptidase domain 22


chr9_+_96096690 3.440 NM_001184706
NM_001184708
NM_178667
Tfdp2


transcription factor Dp 2


chr5_-_149363829 3.355 Ubl3
ubiquitin-like 3
chr12_+_112776311 3.337 NM_173363
NM_178041
Eif5

eukaryotic translation initiation factor 5

chr9_-_116084395 3.336 NM_009371
NM_029575
Tgfbr2

transforming growth factor, beta receptor II

chr16_-_37384915 3.296 Stxbp5l
syntaxin binding protein 5-like
chr15_-_42508294 3.296 NM_009640
Angpt1
angiopoietin 1
chr3_+_122970332 3.253 NM_027135
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr15_+_82105322 3.217 NM_011889
Sept3
septin 3
chr7_-_118006397 3.150 NM_053247
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr19_+_5637459 3.099 NM_009045
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr9_-_116084294 3.059 Tgfbr2
transforming growth factor, beta receptor II
chr3_+_55265654 3.035 NM_001111051
NM_001111052
NM_001195539
NM_001195540
Dclk1



doublecortin-like kinase 1



chr6_+_129483295 3.008 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chrX_-_132738383 2.992 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr6_-_35258102 2.849 NM_172892
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr12_+_109572514 2.828 NM_010010
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr18_+_37979199 2.819 NM_033583
Pcdhgb4
Pcdhgc5
protocadherin gamma subfamily B, 4
protocadherin gamma subfamily C, 5
chr1_+_95132413 2.787 NM_172463
Sned1
sushi, nidogen and EGF-like domains 1
chr3_-_107320881 2.761 NM_172271
Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr15_-_58654964 2.749 NM_175212
Tmem65
transmembrane protein 65
chr8_+_24521967 2.736 NM_013834
Sfrp1
secreted frizzled-related protein 1
chr14_+_35123922 2.703 Glud1
glutamate dehydrogenase 1
chr7_-_30980042 2.695 NM_009795
Capns1
calpain, small subunit 1
chr9_+_44048756 2.675 NM_001081369
Ccdc153
coiled-coil domain containing 153
chr5_-_122952228 2.674 NM_001110140
NM_009722
Atp2a2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

chr3_+_95733228 2.613 Anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr18_+_61204798 2.569 NM_001146268
NM_008809
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr13_+_75977323 2.551 NM_053108
Glrx
glutaredoxin
chr6_+_48986625 2.540 Gpnmb
glycoprotein (transmembrane) nmb
chr14_+_70930491 2.538 NM_145219
Lgi3
leucine-rich repeat LGI family, member 3
chr6_-_35276109 2.536 NM_173375
Fam180a
family with sequence similarity 180, member A
chr16_-_85173978 2.523 App
amyloid beta (A4) precursor protein
chr8_+_34763918 2.504 Gsr
glutathione reductase
chr2_-_25316553 2.501 NM_153557
BC029214
cDNA sequence BC029214
chr18_+_38115192 2.469 NM_153793
Rell2
RELT-like 2
chr16_-_85173944 2.458 NM_001198823
NM_001198824
NM_001198825
NM_001198826
NM_007471
App




amyloid beta (A4) precursor protein




chr8_+_72806863 2.428 NM_001146153
NM_011984
Homer3

homer homolog 3 (Drosophila)

chr8_+_124805995 2.406 NM_009569
Zfpm1
zinc finger protein, multitype 1
chr1_+_6720087 2.382 NM_173868
St18
suppression of tumorigenicity 18
chr3_-_107320831 2.324 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr2_-_25316432 2.306 BC029214
cDNA sequence BC029214
chr7_+_112702873 2.299 NM_011421
Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr7_-_112630662 2.290 NM_028444
Prkcdbp
protein kinase C, delta binding protein
chr9_-_86589782 2.211 NM_008615
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_+_84574217 2.208 NM_001005342
Ypel4
yippee-like 4 (Drosophila)
chr7_+_135667095 2.205 NM_013863
Bag3
BCL2-associated athanogene 3
chr19_+_9063730 2.158 NM_001039959
NM_009643
Ahnak

AHNAK nucleoprotein (desmoyokin)

chr15_+_78757148 2.140 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr10_+_93977597 2.135 NM_172051
Tmcc3
transmembrane and coiled coil domains 3
chr11_-_51464543 2.111 NM_145974
N4bp3
NEDD4 binding protein 3
chr5_+_32438219 2.071 Fosl2
fos-like antigen 2
chr13_-_19711409 2.067 NM_134065
Epdr1
ependymin related protein 1 (zebrafish)
chr9_-_112090150 2.064 NM_033264
NM_001177615
NM_001177620
NM_028755
Arpp21



cyclic AMP-regulated phosphoprotein, 21



chr11_+_67466129 2.058 Gas7
growth arrest specific 7
chr1_-_177422630 2.054 NM_001199003
NM_011880
Rgs7

regulator of G protein signaling 7

chr3_+_54165028 2.051 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr2_+_151931424 2.035 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr16_-_85173851 2.012 App
amyloid beta (A4) precursor protein
chr2_+_167247181 2.003 NM_148929
NM_178371
Slc9a8

solute carrier family 9 (sodium/hydrogen exchanger), member 8

chr11_-_83880574 1.991 Dusp14
dual specificity phosphatase 14
chr6_+_53523365 1.974 NM_172728
Creb5
cAMP responsive element binding protein 5
chr7_-_53176582 1.969 NM_010129
Emp3
epithelial membrane protein 3
chr11_-_51464287 1.964 N4bp3
NEDD4 binding protein 3
chr8_-_63433528 1.961 NM_173876
Clcn3
chloride channel 3
chr11_+_115891591 1.930 NM_172569
Unk
unkempt homolog (Drosophila)
chr8_+_56040211 1.914 Gpm6a
glycoprotein m6a
chr19_-_6915038 1.912 NM_019924
Rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr5_+_35341726 1.910 NM_001163512
Rgs12
regulator of G-protein signaling 12
chr14_+_120674921 1.900 Mbnl2
muscleblind-like 2
chrX_+_143397055 1.872 NM_008312
Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
chrX_-_71269083 1.866 Irak1
interleukin-1 receptor-associated kinase 1
chr7_-_108112785 1.860 NM_183168
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_63097598 1.851 Cyfip1
cytoplasmic FMR1 interacting protein 1
chr4_-_155148591 1.793 NM_147776
Vwa1
von Willebrand factor A domain containing 1
chr9_-_32348863 1.785 NM_008026
Fli1
Friend leukemia integration 1
chrX_+_7299332 1.771 Wdr45
WD repeat domain 45
chr5_-_122952179 1.770 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr5_-_122951791 1.762 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr13_+_30751950 1.736 NM_134068
NM_001037955
Dusp22

dual specificity phosphatase 22

chr2_-_25080180 1.732 NM_146116
Tubb2c
tubulin, beta 2C
chr16_+_56477956 1.721 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr16_-_4879787 1.701 NM_145359
Fam100a
family with sequence similarity 100, member A
chr11_-_59778306 1.698 NM_009026
Rasd1
RAS, dexamethasone-induced 1
chr17_+_53618611 1.691 Rab5a
RAB5A, member RAS oncogene family
chr11_-_116515361 1.677 Cygb
cytoglobin
chr6_+_66986637 1.668 E230016M11Rik
RIKEN cDNA E230016M11 gene
chrX_-_7709907 1.664 NM_026137
Wdr13
WD repeat domain 13
chr11_-_95936914 1.659 NM_001161419
NM_007506
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr11_-_83881811 1.657 NM_019819
Dusp14
dual specificity phosphatase 14
chr2_+_174586283 1.654 Edn3
endothelin 3
chr7_-_133942605 1.647 NM_001177307
Aldoa
aldolase A, fructose-bisphosphate
chr5_-_149364353 1.646 NM_011908
Ubl3
ubiquitin-like 3
chr6_-_122806042 1.633 C3ar1
complement component 3a receptor 1
chr2_-_25947466 1.625 Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr1_-_59030272 1.610 NM_172406
Trak2
trafficking protein, kinesin binding 2
chr7_+_26161818 1.598 4732471J01Rik
RIKEN cDNA 4732471J01 gene
chr7_+_28271928 1.595 NM_018820
Sertad1
SERTA domain containing 1
chr10_+_59740430 1.583 Psap
prosaposin
chr5_-_135223110 1.555 NM_007925
Eln
elastin
chr11_+_100943978 1.553 Coasy
Coenzyme A synthase
chr15_-_97597988 1.536 NM_001177810
NM_001177811
NM_144850
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr18_+_36446680 1.528 Pura
purine rich element binding protein A
chrX_+_71002395 1.524 NM_019587
Plxnb3
plexin B3
chr5_-_74038829 1.516 NM_011890
Sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr15_+_54402914 1.508 NM_178920
Mal2
mal, T-cell differentiation protein 2
chr17_+_35187185 1.496 NM_033444
Clic1
chloride intracellular channel 1
chr19_-_36811137 1.484 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr2_+_156301651 1.475 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_-_54712629 1.470 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr15_-_95485136 1.468 NM_207533
Dbx2
developing brain homeobox 2
chrX_+_136991190 1.455 Prps1
phosphoribosyl pyrophosphate synthetase 1
chr17_-_25891264 1.454 NM_018857
Msln
mesothelin
chr14_+_120724380 1.452 Mbnl2
muscleblind-like 2
chr9_-_29770699 1.447 NM_172290
Ntm
neurotrimin
chr5_-_63157309 1.441 NM_178407
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_108013364 1.439 Atxn7l2
ataxin 7-like 2
chr2_-_164230023 1.430 NM_013592
Matn4
matrilin 4
chr16_-_31314534 1.422 NM_007470
Apod
apolipoprotein D
chr6_+_29718515 1.415 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr2_-_90910439 1.403 Slc39a13
solute carrier family 39 (metal ion transporter), member 13
chr18_-_35658485 1.401 NM_030749
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr9_-_57110250 1.396 NM_028820
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr11_+_67466072 1.380 Gas7
growth arrest specific 7
chr8_-_72498210 1.375 NM_001113346
Gatad2a
GATA zinc finger domain containing 2A
chr7_+_135206153 1.368 NM_001082960
NM_008401
Itgam

integrin alpha M

chr2_+_91097485 1.352 NM_028733
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr8_-_70498472 1.351 NM_177698
Psd3
pleckstrin and Sec7 domain containing 3
chr3_-_94386590 1.343 NM_001082484
NM_029721
Snx27

sorting nexin family member 27

chr11_+_20443315 1.340 Sertad2
SERTA domain containing 2
chrX_+_20265590 1.322 NM_011049
Cdk16
cyclin-dependent kinase 16
chr10_+_96945057 1.286 Dcn
decorin
chr5_+_31117077 1.282 NM_133350
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr1_-_183772442 1.281 NM_133815
Lbr
lamin B receptor
chr8_+_96696677 1.279 Mt2
metallothionein 2
chr1_-_22812829 1.278 Rims1
regulating synaptic membrane exocytosis 1
chr13_-_54867800 1.270 NM_033610
Sncb
synuclein, beta
chr11_-_41995688 1.260 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr7_+_91677480 1.259 Gm2115
predicted gene 2115

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.49 6.21e-04 GO:0007155 cell adhesion
3.46 7.12e-04 GO:0022610 biological adhesion
1.82 3.04e-03 GO:0051179 localization
1.25 1.04e-02 GO:0009987 cellular process
2.09 1.45e-02 GO:0065008 regulation of biological quality
5.43 1.46e-02 GO:0040017 positive regulation of locomotion
4.03 1.97e-02 GO:0040012 regulation of locomotion
9.45 3.51e-02 GO:0060326 cell chemotaxis

Gene overrepresentation in compartment category:

enrichment p-value GO term description
2.10 4.43e-09 GO:0071944 cell periphery
2.11 4.54e-09 GO:0005886 plasma membrane
5.50 6.56e-06 GO:0005578 proteinaceous extracellular matrix
4.10 1.74e-05 GO:0045202 synapse
7.90 2.57e-05 GO:0019717 synaptosome
4.84 3.82e-05 GO:0031012 extracellular matrix
2.96 4.41e-05 GO:0044421 extracellular region part
1.43 1.60e-04 GO:0005737 cytoplasm
7.51 5.41e-04 GO:0044420 extracellular matrix part
2.92 1.17e-03 GO:0031982 vesicle
4.11 1.49e-03 GO:0044456 synapse part
3.32 1.51e-03 GO:0031988 membrane-bounded vesicle
2.96 1.52e-03 GO:0031410 cytoplasmic vesicle
2.40 2.43e-03 GO:0000267 cell fraction
1.28 2.94e-03 GO:0005622 intracellular
1.28 5.09e-03 GO:0044424 intracellular part
2.52 7.30e-03 GO:0005626 insoluble fraction
3.12 1.03e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
5.08 1.24e-02 GO:0012506 vesicle membrane
5.35 2.19e-02 GO:0030136 clathrin-coated vesicle
1.94 2.28e-02 GO:0005576 extracellular region
1.93 2.60e-02 GO:0044459 plasma membrane part
2.41 2.98e-02 GO:0005624 membrane fraction
7.24 3.04e-02 GO:0005604 basement membrane
4.98 3.60e-02 GO:0030659 cytoplasmic vesicle membrane
9.04 3.74e-02 GO:0030665 clathrin coated vesicle membrane
3.61 4.31e-02 GO:0048471 perinuclear region of cytoplasm
4.83 4.46e-02 GO:0044433 cytoplasmic vesicle part
2.96 4.98e-02 GO:0009986 cell surface

Gene overrepresentation in function category:

enrichment p-value GO term description
1.76 5.83e-08 GO:0005515 protein binding
1.36 7.73e-06 GO:0005488 binding
6.47 2.27e-03 GO:0005539 glycosaminoglycan binding
5.79 5.53e-03 GO:0001871 pattern binding
5.79 5.53e-03 GO:0030247 polysaccharide binding
97.63 2.14e-02 GO:0015038 glutathione disulfide oxidoreductase activity
3.40 2.67e-02 GO:0030246 carbohydrate binding
24.41 4.45e-02 GO:0048407 platelet-derived growth factor binding